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Supported by multiple grants from the U.S. National Science Foundation, researchers have comprehensively characterized the properties of a unique type of skeletal tissue with the potential for advancing tissue engineering and regenerative medicine. The tissue, called “lipocartilage,” is packed with fat-filled cells that provide stable internal support so the tissue remains soft and springy like bubbled packaging material.

The fat-filled cells in lipocartilage are called “lipochondrocytes,” which were first recognized in 1854 by Franz Leydig. The tissue is unlike most other types of cartilage, which rely on an external cellular matrix for strength. Led by the University of California, Irvine, the research team showed how lipocartilage cells create and maintain their own lipid reservoirs, remaining constant in size. Unlike other fat cells, lipochondrocytes never shrink or expand in response to food availability. The study was published in Science.

“Lipocartilage’s resilience and stability provide a compliant, elastic quality that’s perfect for flexible body parts such as earlobes or the tip of the nose, opening exciting possibilities in regenerative medicine and tissue engineering, particularly for facial defects or injuries,” says Maksim Plikus, a UC Irvine professor and author on the paper.

“Currently, cartilage reconstruction often requires harvesting tissue from the patient’s rib — a painful and invasive procedure. In the future, patient-specific lipochondrocytes could be derived from stem cells, purified and used to manufacture living cartilage tailored to

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The fires that devastated many in Los Angeles in January 2025 not only scarred the landscape but also changed the air.

A day after the Eaton fire burned through Altadena, California, chlorine levels in the atmosphere reached approximately 40 times the normal amount, while lead peaked at over 100 times the usual level. Atmospheric chlorine can cause respiratory irritation and distress; lead can cause damage to the brain and central nervous system.

“The Los Angeles fires burned homes and cars, which contain electronics, plastics and other synthetic materials that can give off toxic chemicals when they burn,” said Nga Lee “Sally” Ng, a professor at Georgia Tech.

Ng leads the U.S. National Science Foundation-supported Atmospheric Science and Chemistry mEasurement NeTwork (ASCENT), which includes 12 air quality measurement sites nationwide. Each site has state-of-the-art instruments that help us understand aerosols, or tiny particles in the atmosphere. The network is constantly analyzing the chemical constituents of aerosols with a diameter smaller than 2.5 micrometers, referred to as PM2.5, which contribute to more than 90% of the adverse health impacts associated with air pollution.

Researchers in the ASCENT team analyzed data from three locations across Southern California during and after the fire to reveal that certain aerosols carried a unique chemical signature associated with burning synthetic materials in urban fires.

“We now have a very powerful magnifying glass to see

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The manufacturing technique known as 3D printing, now being used everywhere, from aircraft manufacturers to public libraries, has never been more affordable or accessible. Biomedical engineering has particularly benefited from 3D printing as prosthetic devices can be produced and tested more rapidly than ever before. However, 3D printing still faces challenges when printing living tissues, partly due to their complexity and fragility.

Now, with support from the U.S. National Science Foundation, a research team at Boston University (BU) and the Wyss Institute at Harvard University has pioneered the use of gallium, a metal that can be molded at room temperature, to create tissue structures in various shapes and sizes.

This innovative approach to fabrication, engineered sacrificial capillary pumps for evacuation (ESCAPE), was highlighted in a recent study published in Nature, where the team used gallium casts to mold biomaterials. The scaffolds left behind by these casts are then filled with cells cultured to form tissue structures. Vascular structures were some of the first produced using ESCAPE, particularly because of the challenges faced due to blood vessel complexity. Few techniques exist to build large (millimeter-scale) and small (micrometer-scale) structures in scaffolds made of natural materials, making this multiscale fabrication capability a novel approach.

“ESCAPE can be used on several tissue architectures, but we started with vascular forms because blood vessel networks feature many different length scales,”

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