The Notice informs potential applicants that the U.S. Environmental Protection Agency (EPA) is participating, effective immediately, in the notice of funding opportunity (NOFO), RFA-RM-24-010, Complement-ARIE New Approach Methodologies (NAMs) Technology Development Centers (UM1 Clinical Trial Optional). Changes to the NOFO are shown below.

The following section of RFA-RM-24-010 was modified:

Part I. Overview Information

Participating Organization(s)

Currently Reads:

National Institutes of Health (NIH)

Modified to Read (changes shown in bold italics):

National Institutes of Health (NIH)

U.S. Environmental Protection Agency (EPA)

All other aspects of the NOFO remain the same.

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Alzheimer’s disease (AD) is defined, in part, by the appearance of extracellular amyloid deposits. Supported by genetic studies, the amyloid cascade is a leading hypothesis for the cause and pathogenesis of AD. Despite the intensive efforts that have been made in understanding amyloid and other pathological processes in AD, current approved interventions for AD have shown only modest effects in modifying clinical symptoms; none have been efficacious for slowing disease progression as demonstrated through clinical outcome measures.

Recent developments in the field of genetics have significantly advanced understanding of the etiology of AD. More than two dozen genes are now known to be associated with late-onset AD (LOAD). Using a combination of genome-wide association studies (GWAS),

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The purpose of this Notice of Special Interest (NOSI) is to promote intervention research through investigator-initiated applications that aim to study ways to mitigate financial hardship for individuals impacted by a cancer diagnosis, including patients receiving cancer treatment, survivors, and caregivers.

Background

The 2021 Annual Report to the Nation on the Status of Cancer estimated the annual patient economic burden of cancer care to be $21 billion in 2019. Part of that burden is felt as financial hardship for patients. Financial hardship refers to the collective impact of out-of-pocket costs and lost income, psychological worry about finances, and behavioral coping responses that include delaying or foregoing recommended care and other necessities to save money. Cancer-related financial hardship is the product of varied risk factors,

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