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Notice of Special Interest (NOSI): Genetic Underpinnings of Endosomal Trafficking as a Pathological Hub in Alzheimer’s Disease (AD) and AD-Related Dementias (ADRD)
Alzheimer’s disease (AD) is defined, in part, by the appearance of extracellular amyloid deposits. Supported by genetic studies, the amyloid cascade is a leading hypothesis for the cause and pathogenesis of AD. Despite the intensive efforts that have been made in understanding amyloid and other pathological processes in AD, current approved interventions for AD have shown only modest effects in modifying clinical symptoms; none have been efficacious for slowing disease progression as demonstrated through clinical outcome measures.
Recent developments in the field of genetics have significantly advanced understanding of the etiology of AD. More than two dozen genes are now known to be associated with late-onset AD (LOAD). Using a combination of genome-wide association studies (GWAS),
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Notice of Special Interest (NOSI): Addressing Cancer-Related Financial Hardship to Improve Patient Outcomes
The purpose of this Notice of Special Interest (NOSI) is to promote intervention research through investigator-initiated applications that aim to study ways to mitigate financial hardship for individuals impacted by a cancer diagnosis, including patients receiving cancer treatment, survivors, and caregivers.
Background
The 2021 Annual Report to the Nation on the Status of Cancer estimated the annual patient economic burden of cancer care to be $21 billion in 2019. Part of that burden is felt as financial hardship for patients. Financial hardship refers to the collective impact of out-of-pocket costs and lost income, psychological worry about finances, and behavioral coping responses that include delaying or foregoing recommended care and other necessities to save money. Cancer-related financial hardship is the product of varied risk factors,
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Notice to Rescind NOT-CA-18-031 “NIH Applicant Assistance Program (AAP) for New or Previously Unawarded Small Businesses”
Notice Number:
NOT-OD-25-065
Key Dates
Release Date:
January 17, 2025
Related Announcements
Issued by
Office of The Director, National Institutes of Health (OD)
National Cancer Institute (NCI)
Purpose
The purpose of this notice is to rescind NOT-CA-18-031 NIH Applicant Assistance Program (AAP) for New or Previously Unawarded Small Businesses, effective immediately.
For tips and resources on preparing your application,
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Participating Organization(s)
National Institutes of Health (NIH)
Components of Participating Organizations
National Institute on Aging (NIA)
Funding Opportunity Title
NIA Predoctoral Fellowship Award to Promote Broad Participation in Translational Research for AD/ADRD (F31 Clinical Trial Not Allowed)
Activity Code
F31 Predoctoral Individual National Research Service Grant Award
Announcement Type
Related Notices
August 31, 2022– Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198. August 5, 2022– Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.
Funding Opportunity Number (FON)
PAR-24-333
Companion Notice of Funding Opportunity
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