RSS feed source: National Science Foundation
A new computational tool developed with support from the U.S. National Science Foundation could greatly speed up determining the 3D structure of RNAs, a critical step in developing new RNA-based drugs, identifying drug-binding sites and using RNAs in other biotechnology and biomedicine applications.
The tool, NuFold, leverages state-of-the-art machine learning techniques to predict the structure of a wide variety of RNA molecules from their sequences. This new capability will allow researchers to visualize what a given RNA structure could look like based on its sequence and identify its potential use in drug delivery, disease treatment and other applications. The research leading to NuFold was published in Nature Communications.
RNAs are critical biological molecules — encoding information, like DNA, and performing cellular functions, like proteins — but relatively few RNA structures have been determined through experimentation thus far, which severely limits understanding of their functions. For example, RNAs in the NSF-funded Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB) represent only about 3% of total entries. Experimentally determining RNA structures is often time-consuming and costly. By providing a path to reliably predicting RNA structure from sequence, NuFold could greatly expedite the discovery of RNA function and enable quicker development of RNA-based therapeutics and technologies.
RSS feed source: National Science Foundation
* WHAT…Flooding caused by excessive rainfall continues to be possible. * WHERE…Portions of southeast Louisiana, including the following parishes, Assumption, Central Plaquemines, Central Tangipahoa, Coastal Jefferson Parish, East Baton Rouge, East Feliciana, Eastern Ascension, Eastern Orleans, Iberville, Lower Jefferson, Lower Lafourche, Lower Plaquemines, Lower St. Bernard, Lower Tangipahoa, Lower Terrebonne, Northern Livingston, Northern St. Tammany, Northern Tangipahoa, Pointe Coupee, Southeast St. Tammany, Southern Livingston, Southwestern St. Tammany, St. Charles, St. Helena, St. James, St. John The Baptist, Upper Jefferson, Upper Lafourche, Upper Plaquemines, Upper St. Bernard, Upper Terrebonne, Washington, West Baton Rouge, West Feliciana, Western Ascension and Western Orleans and southern Mississippi, including the following areas, Amite, Northern Hancock, Northern Harrison,
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…The Flood Advisory continues for the following rivers in Oklahoma… Cimarron River at Kenton 2NE affecting Cimarron County. For the Cimarron River…including Kenton 2NE…elevated river levels are forecast. * WHAT…Flooding caused by excessive rainfall continues. * WHERE…Cimarron River at Kenton 2NE. * WHEN…Until this evening. * IMPACTS…At 11.0 feet, Bankfull stage. Water is up to the lowest natural banks but within secondary banks. Low water crossings upstream and downstream are likely flooded. Fences below the secondary bank could sustain damage. No other known threats. * ADDITIONAL DETAILS… – At 9:15 AM CDT Wednesday the stage was 4.7 feet. – Bankfull stage is 11.0 feet. – Forecast…The river is expected to rise
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Snow returns to the Alaska Range, with snow levels falling to road level. Snow rates may be heavy at times with 3 to 7 inches of snow expected by this evening. Visibility could be reduced to around a half mile during the heaviest snowfall. Snow is expected to change over to a rain/snow mix by this afternoon. This will bring slick road conditions overnight tonight as everything begins to freeze over. Travelers should use extra caution as they traverse the Alaska Range along the Parks and Richardson Highway.
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