This Notice of Special Interest (NOSI) encourages research on the use of digital technology for early detection and monitoring of cognitive and functional decline in persons with Alzheimer’s disease (AD) and AD-related dementias (ADRD). This NOSI is a reissue of NOT-AG-21-048.

Background

Early diagnosis and monitoring of AD/ADRD is an unmet need and a major goal in the Department of Health and Human Services’ National Plan to Address Alzheimer’s Disease. There is evidence that the functional, psychological, pathological, and physiological changes underlying AD/ADRD may emerge many years prior to the clinical manifestation of cognitive symptoms, prompting this call to identify earlier indicators of disease risk and subclinical disease burden.

Many current biomarkers for early detection of prodromal AD/ADRD (e.g., PET/MRI imaging)

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