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Notice of Change to Receipt Date and the Expiration Date for RFA-RM-24-010: Complement-ARIE New Approach Methodologies (NAMs) Technology Development Centers (UM1 Clinical Trial Optional)
Notice Number:
NOT-RM-25-001
Release Date:
January 15, 2025
Related Announcements
December 10, 2024 – Complement-ARIE New Approach Methodologies (NAMs) Technology Development Centers (UM1 Clinical Trial Optional). See NOFO RFA-RM-24-010.
Issued by
Purpose
The purpose of this notice is to change the new application receipt date and expiration date for Complement-ARIE New Approach Methodologies (NAMs) Technology Development Centers (UM1 Clinical Trial Optional) RFA-RM-24-010. The new application receipt date is March 18, 2025. The new expiration date: March 19, 2025. Changes to the Notice of
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Notice of Special Interest (NOSI): Common Mechanisms and Interactions Among Neurodegenerative Diseases
Etiologic and therapeutic research on dementia has focused either on individual disease syndromes (e.g., Alzheimers disease (AD), Lewy Body Dementia (LBD), Frontotemporal Dementia (FTD), Vascular Contributions to Cognitive Impairment and Dementia (VCID) or distinct neurodegenerative processes (e.g., beta-amyloid, HPF-tau, alpha-synuclein, TDP-43, small vessel changes). Aside from descriptive, postmortem neuropathology, different neurodegenerative diseases have generally been investigated in isolation from one another. There are few models for studying whether and how neurodegenerative disease processes relate to one another.
At autopsy, many patients with dementia, particularly older individuals, exhibit multiple neuropathological changes. In addition to tau tangles and beta-amyloid plaques, vascular changes, Lewy bodies, and TDP-43 inclusions are often present. The likelihood of antemortem dementia increases with co-occurring postmortem neuropathological burden. However, despite considerable evidence of interactions between
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In the rapidly evolving landscape of digital innovation, staying adaptable isn’t just a strategy—it’s a survival skill. “Everybody has a plan until they get punched in the face,” says Luis Niño, digital manager for technology ventures and innovation at Chevron, quoting Mike Tyson.
Drawing from a career that spans IT, HR, and infrastructure operations across the globe, Niño offers a unique perspective on innovation and how organizational microcultures within Chevron shape how digital transformation evolves.
Centralized functions prioritize efficiency, relying on tools like AI, data analytics, and scalable system architectures. Meanwhile, business units focus on simplicity and effectiveness, deploying robotics and edge computing to meet site-specific needs and ensure safety.
“From a digital transformation standpoint, what I have learned is that you have to tie your technology to what outcomes drive results for both areas, but you have to allow yourself to be flexible,
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RSS feed source: National Institute of Health
Products you use every day are carefully formulated in a lab. Experts at NIST are now working to revolutionize how those products are made.
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