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NSF Financial Assistance awards (grants and cooperative agreements) made on or after October 1, 2024, will be subject to the applicable set of award conditions, dated October 1, 2024, available on the NSF website. These terms and conditions are consistent with the revised guidance specified in the OMB Guidance for Federal Financial Assistance published in the Federal Register on April 22, 2024.

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Humans aren’t capable of regrowing limbs like some salamanders or full organs like some snails and zebrafish, but we do renew some of our cells, including the absorptive lining of our intestines. In contrast to the relatively minor turnover of cells seen in human intestines, some snakes, including boas and pythons, undergo extensive regenerative transformation of their intestine upon feeding. New research supported by the U.S. National Science Foundation has found that the method these snakes use to renew their guts, while different from the process humans use for regular cell renewal, is similar to mechanisms observed in mammalian wound healing and to how human intestines respond to a particular form of gastric bypass. This discovery increases researchers’ understanding of intestinal physiology and could have applications in treating metabolic and gastrointestinal disorders like diabetes and celiac disease, and possibly even cancer.

Humans regularly renew intestinal cells by activating stem cells found in microscopic caverns in the intestinal wall known as intestinal crypts. Boas and pythons don’t have these crypts but regenerate their intestines after feeding in one of the most extreme examples of intestinal regeneration found in the animal kingdom — from shrunken and nearly non-functioning to double the size and with a rebuilt structure capable of digesting and absorbing their meal. The new research solved key elements of the mystery of how

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This week, Director Sethuraman Panchanathan underscored the progress and accomplishments that NSF investments are having on innovation and research.

The director traveled to Omaha, Nebraska, to attend the 28th NSF Established Program to Stimulate Competitive Research (NSF EPSCoR) National Conference hosted by the University of Nebraska at Omaha. Panchanathan met with University of Nebraska System President Jeffrey Gold and delivered a keynote speech highlighting NSF EPSCoR’s transformative impact in creating an inclusive research ecosystem in the United States. The director emphasized EPSCoR’s vital role in response to the “Chips and Science Act of 2022,” which set targets for investments to advance innovative ideas in STEM and rapidly translate them into solutions.

Credit: Amanda Greenwell/NSF

EPSCoR conference on October 15,2024. With Dr. Panch giving keynote remarks; Dr. Panch meets with the University of Nebraska System president, Jeffrey Gold; and A researcher presents their poster to Dr. Panch.

The EPSCoR program supports NSF’s overall goal of promoting the progress of scientific development. EPSCoR continues to evolve and adapt to fuel discoveries by building research infrastructures, fostering innovation and enhancing collaboration in jurisdictions that have not always been represented before in the research landscape.

Later in the week, the director met with Brian Schmidt, a Nobel Prize laureate in physics who NSF has supported, and delegates from the

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During its current revision, the Baldrige Excellence Framework®, the core document of the Baldrige Program, is undergoing revolutionary change—being reorganized, simplified, and refocused—to make it as easy to use as possible and to expand its value

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