The purpose of this Notice is to correct the instructions for two areas of the Research Strategy in Section IV (Application and Submission Information) of PAR-25-153 “Assay development and screening for discovery of chemical probes, drugs or immunomodulators (R01 Clinical Trial Not Allowed)”.

Section IV. Application and Submission Information

Part 2. Content and Form of Application Submission 

Research Plan

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Research Strategy: Applicants should address the following topics as they pertain to the proposed research project:

Importance of the Research (Significance and Innovation): Applicants should address why the chosen target or pathway is significant for the proposed chemical probe/drug discovery project, and whether the probe will provide new insight into important cancer targets and processes. Preliminary data or published information

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