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U.S. National Science Foundation

Directorate for Technology, Innovation and Partnerships
     Translational Impacts

Full Proposal Deadline(s) (due by 5 p.m. submitting organization’s local time):

     Proposals Accepted Anytime

Table Of Contents

Summary of Program Requirements

Introduction Program Description Award Information Eligibility Information Proposal Preparation and Submission Instructions Proposal Preparation Instructions Budgetary Information Due Dates Research.gov/Grants.gov Requirements NSF Proposal Processing and Review Procedures Merit Review Principles and Criteria Review and Selection Process Award Administration Information Notification of the Award Award Conditions Reporting Requirements Agency Contacts Other Information Important Information And Revision Notes

Proposers must have either 1) received a prior award from NSF in a scientific or engineering field relevant to the proposed innovation that is currently active or that has been active within five years from the date of the NSF National I-Corps Teams proposal submission or 2) have participated

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Synopsis

Machine Learning and Artificial Intelligence (AI) are enabling extraordinary scientific breakthroughs in fields ranging from protein folding, natural language processing, drug synthesis, and recommender systems to the discovery of novel engineering materials and products. These achievements lie at the confluence of mathematics, statistics, engineering and computer science, yet a clear explanation of the remarkable power and also the limitations of such AI systems has eluded scientists from all disciplines. Critical foundational gaps remain that, if not properly addressed, will soon limit advances in machine learning, curbing progress in artificial intelligence. It appears increasingly unlikely that these critical gaps can be surmounted with increased computational power and experimentation alone. Deeper mathematical understanding is essential to ensuring that AI can be harnessed to meet the future needs of society and enable broad scientific discovery, while forestalling the unintended consequences of a disruptive technology.  

The National

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Synopsis

The Mathematical Biology Program supports research in all areas of mathematical sciences with relevance to the biological sciences. Successful proposals must demonstrate mathematical innovation, biological relevance and significance, and strong integration between mathematics and biology.

Some projects of interest to the Mathematical Biology Program may include development of mathematical theories, methodologies, and tools traditionally seen in other disciplinary programs within the Division of Mathematical Sciences. In general, if a proposal is appropriate for review by more than one NSF program, it is advisable to contact the program officers handling each program to determine when and where the proposal should be submitted and to facilitate the review process.

The Mathematical Biology Program regularly seeks joint reviews of proposals with programs in the Directorates of Biological Sciences and other relevant programs. Investigators are encouraged to discuss their project with program officers in relevant areas to

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On July 10, 2025, NSF issued an Important Notice providing updates to the agency’s research security policies, including a research security training requirement, Malign Foreign Talent Recruitment Program annual certification requirement, prohibition on Confucius institutes and an updated FFDR reporting and submission timeline.

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