This Notice is to inform the extramural research community that the National Institutes of Health (NIH) Tobacco Regulatory Science Program (TRSP), participating NIH Institutes and Centers (ICs), and the United States Food and Drug Administration (FDA) Center for Tobacco Products (CTP) intend to issue a Notice of Funding Opportunity (NOFO) seeking R03 Small Grant Program applications for new High-Priority Research Topics in Tobacco Regulatory Science (Clinical Trial Optional). This NOFO will seek to support New Investigators (including Early-Stage Investigators and investigators who have not successfully competed for independent NIH funding), in the biomedical, behavioral, and social sciences who are in the early stages of establishing independent careers in tobacco regulatory research but have not yet

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