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NSF 24-121

August 28, 2024

Dear Colleagues:

Understanding the neurobiological mechanisms that underlie neural, physiological, and behavioral responses to anthropogenic environmental change is of vital importance in today’s rapidly evolving world. The nervous system serves as an interface between an organism and its environment, and through it, perceives, responds, and adapts to change. Anthropogenic stressors such as noise pollution, ocean acidification, chemical pollution, temperature fluctuation and other human-generated environmental perturbations pose severe threats to organisms, thereby affecting biodiversity and ecosystem services. Research in the area of neurobiology in changing ecosystems holds promise to reveal novel scientific insights that will contribute to understanding neural adaptation and resilience at molecular, biophysical, cellular, and circuit level (Michaiel and Bernard 2022; O’Donnell 2018).

Opportunities for investigation of neurobiology in changing ecosystems specifically cover modulatory, homeostatic, adaptive, and/or

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NSF 24-120

August 28, 2024

Dear Colleagues:

Plant genetic transformation, a process of introducing DNA, RNA, and proteins into plant cell/tissue and the regeneration of transformed materials, is of vital importance for both basic and applied research. In basic research, the generation of knock-out mutants, targeted mutagenesis, or over-expressing lines by plant transformation is a key approach for the functional characterization of genes. In applied research, genetic transformation enables genome editing and transgenesis that allows precise and knowledge-based gene modifications for plant breeding.

Except for Arabidopsis thaliana and a few other species from the Brassicaceae family, which can be transformed using non-tissue culture-based technique, most plant species require complex transformation and regeneration protocols with extensive in vitro culture procedures. These protocols are time-consuming, expensive, and often technically demanding. For many plant species, regeneration

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PROGRAM BASICS

What is the goal of the NSF Pathways to Enable Open-Source Ecosystems (POSE) program?

The goal of the NSF POSE program is to fund new open-source ecosystem (OSE) managing organizations, each responsible for the creation and maintenance of infrastructure needed for efficient and secure operation of an OSE focused on a specific open-source product or class of products. The early and intentional formation of such managing organizations is expected to enhance the distributed development process, improve coordination of developer contributions, increase the size of the user community, and enable more focused route to impactful technologies.

The POSE program is not intended to fund:

compensation for the developers of the open-source research products, including tools and artifacts; existing, well-resourced open-source communities, organizations, and/or ecosystems; or the development of products that are unavailable for open use.

Proposers working on a product where

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U.S. National Science Foundation

Directorate for Engineering
     Emerging Frontiers and Multidisciplinary Activities

Letter of Intent Due Date(s) (required) (due by 5 p.m. submitting organization’s local time):

     November 15, 2024

Preliminary Proposal Due Date(s) (required) (due by 5 p.m. submitting organization’s local time):

     January 14, 2025

Full Proposal Deadline(s) (due by 5 p.m. submitting organization’s local time):

     April 15, 2025

Important Information And Revision Notes

Prospective PIs interested in submitting a TRAILBLAZER proposal must submit a Letter of Intent (LOI) by November 15, 2024. Refer to Section V. Proposal Preparation and Submission Instructions for further details. This is a change as compared to the FY24 TRAILBLAZER solicitation.

Also new for the FY25 Trailblazer solicitation, preliminary proposals are required. Full proposals will only be accepted for review from those PIs who are invited to submit a full proposal following review of their preliminary proposal.

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